Statistics in diagnostic medicine Peter Schlattmann Interferences in immunoassays: review and practical algorithm Loris Wauthier, Mario Plebani, Julien Favresse The value proposition of integrative diagnostics for (early) detection of cancer. On behalf of the EFLM interdisciplinary Task and Finish Group “CNAPS/CTC for early detection of cancer” Matthias F. Froelich, Ettore Capoluongo, Zsolt Kovacs, Simon J. Patton, Evi S. Lianidou, Verena Haselmann Benchmarking medical laboratory performance: survey validation and results for Europe, Middle East, and Africa Wolfgang Huf, Mike Mohns, Zoe Bünning, Rebecca Lister, Tetiana Garmatiuk, Christoph Buchta, Brigitte Ettl Pre-analytical stability of serum biomarkers for neurological disease: neurofilament-light, glial fibrillary acidic protein and contactin-1 Zoë Y. G. J. van Lierop, Inge M. W. Verberk, Kees W. J. van Uffelen, Marleen J. A. Koel-Simmelink, Lisanne in ’t Veld, Joep Killestein, Charlotte E. Teunissen Filling in the GAPS: validation of anion gap (AGAP) measurement uncertainty estimates for use in clinical decision making Jessica L. Gifford, Isolde Seiden-Long Implementation and challenges of portable blood gas measurements in air medical transport Anjana Murali, Francis X. Guyette, Christian Martin-Gill, Marion Jones, Matthew Kravetsky, Sarah E. Wheeler Calculation of the estimated glomerular filtration rate using the 2021 CKD-EPI creatinine equation and whole blood creatinine values measured with Radiometer ABL 827 FLEX Lu Song, Vincent Buggs, Vishnu Amaram Samara, Shadfar Bahri Dubiously increased FT4 and FT3 levels in clinically euthyroid patients: clinical finding or analytical pitfall? Martin Külz, Stephan Fellner, Jörg Rocktäschel, Uta Ceglarek, Anja Willenberg, Jürgen Kratzsch Two co-inherited hemoglobin variants revealed by capillary electrophoresis during quantification of glycated hemoglobin Giovanni Antonello, Carlo Lo Monaco, Patrizia Napoli, Daniela Solimando, Cristina Curcio, Giuseppina Barberio, Sauro Maoggi, Giovanni Ivaldi, Marco Nigra Determination of individual bile acids in acute respiratory distress syndrome reveals a specific pattern of primary and secondary bile acids and a shift to the acidic pathway as an adaptive response to the critical condition Lars-Olav Harnisch, Diana Mihaylov, Thomas Bein, Christian Apfelbacher, Michael Kiehntopf, Michael Bauer, Onnen Moerer, Michael Quintel Evaluation of a faecal calprotectin method using the OC-SENSOR PLEDIA Shane O’Driscoll, Carolyn Piggott, Sally C. Benton Reference intervals for Sysmex XN hematological parameters as assessed in the Dutch Lifelines cohort Joost L. van Pelt, Stefanie Klatte, Talent Hwandih, Andrei Barcaru, Ineke J. Riphagen, Jo Linssen, Stephan J.L. Bakker High incidence of discrepancies in new Siemens assay – a comparison of cardiac troponin I assays Rasmus Bo Hasselbalch, Jonas Henrik Kristensen, Nicoline Jørgensen, Nina Strandkjær, Bashir Alaour, Shoaib Afzal, Michael Marber, Henning Bundgaard, Kasper Karmark Iversen Effect of BNT162b2 booster dose on anti-SARS-CoV-2 spike trimeric IgG antibodies in seronegative individuals Gian Luca Salvagno, Brandon M. Henry, Laura Pighi, Simone De Nitto, Gianluca Gianfilippi, Giuseppe Lippi The role of neutralizing antibodies by sVNT after two doses of BNT162b2 mRNA vaccine in a cohort of Italian healthcare workers Maria Infantino, Mariangela Manfredi, Lorenzo Stacchini, Claudia Cosma, Valentina Grossi, Barbara Lari, Edda Russo, Amedeo Amedei, Maurizio Benucci, Francesca Veneziani, Patrizia Casprini, Cateno Mario Catalano, Giuseppe Cirrincione, Guglielmo Bonaccorsi, Adolfo Pompetti Continuous monitoring of SARS-CoV-2 seroprevalence in children using residual blood samples from routine clinical chemistry Felix Wachter, Adrian P. Regensburger, Antonia Sophia Peter, Ferdinand Knieling, Alexandra L. Wagner, David Simon, André Hoerning, Joachim Woelfle, Klaus Überla, Antje Neubert, Manfred Rauh Prognostic significance of soluble CD25 in patients with sepsis: a prospective observational study Chun-Mei Huang, Xin-Jie Xu, Wen-Qi Qi, Qin-Min Ge Diagnostic accuracy of the ultrasensitive S-PLEX SARS-CoV-2 N electrochemiluminescence immunoassay Giuseppe Lippi, Brandon M. Henry, Martina Montagnana, Mario Plebani Life-threatening autoimmune hemolytic anemia following mRNA COVID-19 vaccination: don’t be too prudent with the red gold Sander De Bruyne, Stijn Van Landeghem, Alexander Schauwvlieghe, Lucien Noens CSF-interleukin 6 for early diagnosis of ventriculitis in a broad intensive care setting Sylvia Mink, Wolfgang List, Patrick Reimann, Peter Fraunberger Clearance of macro-TSH from the circulation is slower than TSH Ayato Yamada, Naoki Hattori, Takeshi Matsuda, Norito Nishiyama, Akira Shimatsu Biological variation and reference change value as decision criteria in clinical use of tumor biomarkers. Are they really useful? Ruggero Dittadi, Aline S.C. Fabricio, Massimo Gion Testing for anti-Müllerian hormone: analytical performances and usability of a point-of-care assay Louise Guillaume, Virginie Chapelle, Carmen Minea, Damien Gruson Diagnostic performance characteristics of the Quanta Flash Rheumatoid Factor assay in a consecutive Dutch patient cohort Lotte Wieten, Jan G.M.C. Damoiseaux, Bram Lestrade, Liesbeth E. Bakker-Jonges Trimester-specific reference values for the anticardiolipin antibody by chemiluminescence immunoassay in healthy pregnancy Rui Gao, Xinai Yue, Wanrong Huang, Fan Yu, Lang Qin 4th National Point of Care Testing Symposium |